Serum zinc levels in hepatocellular carcinoma.

Status of serum alpha feto-protein (AFP) and midkine (MDK) levels in patients with hepatocellular carcinoma

Introduction: Hepatocellular carcinoma (HCC) is sixth common cancers worldwide and predominant in Asia and Africa. A number of evidence suggests a possible role of midkine (MDK) and α-fetoprotein (AFP) in the pathogenesis of hepatocellular carcinoma (HCC). Materials and methods: We studied MDK and AFP in patients with HCC or in healthy controls. MDK and AFP was measured by enzyme linked immuno...

Hepatocellular Carcinoma in Sheep

Serum cytokine levels in patients with hepatocellular carcinoma.

The role played by the microenvironment in cancer induction, promotion and progression is crucial. Emerging evidence suggests that cytokines, chemokines and growth factors are major players in carcinogenesis. Therefore, a detailed understanding of factors and mechanisms associated with the processes leading from inflammation to cancer could improve the therapeutic strategies against this diseas...

Elevated serum levels of Chromogranin A in hepatocellular carcinoma

BACKGROUND During the past three decades, the incidence of hepatocellular carcinoma in the United States has tripled. The neuroendocrine character has been observed in some tumor cells within some hepatocellular carcinoma nodules and elevated serum chromogranin A also been reported in patients with hepatocellular carcinoma. The aim of this work was to investigate the role of serum concentration...

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...